The thrombin receptor PAR4 supports visceral adipose tissue inflammation

S Kleeschulte, V Fischinger, L Öhlke, J Bode… - Naunyn-Schmiedeberg's …, 2024 - Springer
… of PAR4 attenuated these measures of visceral obesity … differentiation and lipid deposition
during diet-induced obesity have … if these emerging PAR4 antagonists can provide additional …

Life without Proteinase Activated Receptor 2 (PAR2) Alters Body Composition and Glucose Tolerance in Mice

TH Reynolds, SJ Ives - Nutrients, 2022 - mdpi.com
… Although a PAR2 antagonists can prevent diet-induced obesity … of PAR2 would abolish, or
attenuate, the age-associated … of PAR2 did not attenuate the increase in adiposity associated …

Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition

JY Her, Y Lee, SJ Kim, G Heo, J Choo… - American Journal …, 2021 - journals.physiology.org
… this metabolic dysfunction was alleviated by a PAR2 antagonist … were higher in IBD tissues,
and colitis was attenuated by … between UC and diet-induced obesity has demonstrated that …

The pathological impact of PAR2 on hepatic insulin resistance

HH Chung - Hepatology, 2023 - journals.lww.com
expressions in diet-induced obesity linked to adipose tissue inflammation were reversed
by the PAR2 antagonist… overexpression in HepG2 cells significantly attenuated AMPK-mediated …

PAR2 promotes impaired glucose uptake and insulin resistance in NAFLD through GLUT2 and Akt interference

AM Shearer, Y Wang, EK Fletcher, R Rana… - Hepatology, 2022 - journals.lww.com
dietinduced obesity HFD model that was ascribed variously to … cells present in visceral
adipose tissue or in liver itself. [ 9,10 ] … The PAR2 calcium signal was significantly attenuated (p < …

[PDF][PDF] A pref-1-controlled non-inflammatory mechanism of insulin resistance

Y Huang, D Cui, L Chen, H Tong, H Wu, GK Muller… - Iscience, 2023 - cell.com
Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with
PAR2 expression are attenuated by PAR2 antagonism. FASEB J 27, 4757-4767. 10.1096/fj.13-…

[HTML][HTML] PAR2 Deficiency Induces Mitochondrial ROS Generation and Dysfunctions, Leading to the Inhibition of Adipocyte Differentiation

YJ Park, B Lee, DH Kim, EB Kwon, Y Go… - … Medicine and Cellular …, 2021 - hindawi.com
… Also, a PAR2 antagonist elevated mitochondrial reactive … ing promotes diet-induced obesity
and adipose inflammation,… dysfunction correlating with PAR2 expression are attenuated

Innate immunity in diabetic kidney disease

SCW Tang, WH Yiu - Nature Reviews Nephrology, 2020 - nature.com
… effects were attenuated by treatment with an ETA antagonist. … and free fatty acid-induced
pro-inflammatory cytokine … high-fat diet-induced obesity and metabolic syndrome 141 . Moreover…

Crosstalk between mast cells and adipocytes in physiologic and pathologic conditions

D Elieh Ali Komi, F Shafaghat, M Christian - Clinical reviews in allergy & …, 2020 - Springer
… process of obesity and IR after employing diet-induced obesity [78]… and the possibility of
blocking it by antagonists makes it a … its benefits in attenuation of adiposity, AT inflammation, and …

[HTML][HTML] PAR2: the cornerstone of pancreatic diseases

P Suhaj, T Olejar, R Matej - Physiological Research, 2022 - ncbi.nlm.nih.gov
… rat adipose tissue, an increase in PAR2 expression correlates with … The use of a PAR2
antagonist results in decreased … P2pal-18S in NSCLC attenuates ERK phosphorylation that forces …